Description
MART-1isanendogenousmelanoma-associatedantigenthatcanbeusedinthedevelopmentofvaccinestoinduceanimmuneresponseagainstcancerouscellsexpressingmelanomaantigens.VaccinesusingMART-1conjugateshaveshownsomeanticancerchemotherapeuticefficacyinclinicaltrials.
References
ChodonT,Comin-AnduixB,ChmielowskiB,etal.AdoptiveTransferofMART-1T-CellReceptorTransgenicLymphocytesandDendriticCellVaccinationinPatientswithMetastaticMelanoma.ClinCancerRes.2014May1;20(9):2457-65.PMID:24634374.
RomanoE,MichielinO,VoelterV,etal.MART-1peptidevaccinationplusIMP321(LAG-3Igfusionprotein)inpatientsreceivingautologousPBMCsafterlymphodepletion:resultsofaPhaseItrial.JTranslMed.2014Apr12;12:97.PMID:24726012.