Description
Men10376isapeptideantagoNISTatneurokinin-2(NK2)receptors.Men10376decreasesstretch-activatedcontractilityinairwaysmoothmuscletissueexvivoandinhibitsOVA-inducedbronchoconstrictioninvivo.
Men10376isapeptideantagoNISTatneurokinin-2(NK2)receptors.Men10376decreasesstretch-activatedcontractilityinairwaysmoothmuscletissueexvivoandinhibitsOVA-inducedbronchoconstrictioninvivo.
CasNo. | 135306-85-3 |
---|---|
Purity | ≥95% |
Formula | C57H68N12O10 |
FormulaWt. | 1081.25 |
IUPACName | 3-amino-4-[[1-[[1-[[1-[[1-[[1-[(1,6-diamino-1-oxohexan-2-yl)amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-oxobutanoicacid |
Synonym | NeurokininA(4-10),tyr(5)-trp(6,8,9)-lys(10)- |
Appearance | Whitetooffwhitepowder |
StoreTemp | -20°C |
---|---|
ShipTemp | Ambient |
InfoSheet | M1752InfoSheetPDF |
---|
HernandezJM,CoxG,JanssenLJ.Involvementoftheneurokinin-2receptorinairwaysmoothmusclestretch-activatedcontractionsassessedinperfusedintactbovinebronchialsegments.JPharmacolExpTher.2008Nov;327(2):503-10.PMID:18719290.
KrishnakumarS,HolmesEP,MooreRM,etal.Non-adrenergicnon-cholinergicexcitatoryinnervationintheairways:roleofneurokinin-2receptors.AutonAutacoidPharmacol.2002Aug;22(4):215-24.PMID:12656947.