Myelin basic protein (1-11) is a peptide antigen fragment that may bind to receptors expressed by T cells involved in autoimmune diseases such as multiple sclerosis. Administration of myelin basic protein (1-11) decreases expression of IL-12 in the lymph nodes of mice with experimental autoimmune encephalitis (EAE), an animal model of multiple sclerosis; IL-12 appears to play a protective role against EAE pathology and development.
| Cas No. | 106128-98-7 |
|---|---|
| Purity | ≥95% |
| Formula | C52H88N22O17 |
| Formula Wt. | 1293.42 |
| IUPAC Name | N-Acetyl-L-alanyl-L-seryl-L-glutaminyl-L-lysyl-N5-(diaminomethylen)-L-ornithyl-L-prolyl-L-seryl-L-glutaminyl-N5-(diaminomethylen)-L-ornithyl-L-histidylglycin |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | M9643 Info Sheet PDF |
|---|
Buenafe AC, Sherwood C, Moes N, et al. Recombinase-activating gene 1-associated expression of the myelin basic protein 1-11-specific transgenic T-cell receptor in H-2b mice. J Neurosci Res. 2009 Jan;87(1):42-9. PMID: 18752298.
Zhang GX, Xu H, Kishi M, et al. The role of IL-12 in the induction of intravenous tolerance in experimental autoimmune encephalomyelitis. J Immunol. 2002 Mar 1;168(5):2501-7. PMID: 11859144.
