Description
Chlorophyllinisasemi-syntheticderivativeofchlorophyllthatiscommerciallyusedasafoodadditiveandcoloringagent.Chlorophyllinexhibitsanti-angiogenic,anticancerchemotherapeutic,andchemopreventiveactivities.Chlorophyllincanactasaphotosensitizer,inducingapoptosisandautophagyunderUVlightinbladdercancercells.Invivo,chlorophyllindecreasesexpressionofHDACs,VEGF,VEGFR2,andHIF-1αandsuppressesWnt/β-cateninsignaling.Invitro,thiscompounddecreasesDNAadductformationinducedbybenzo[a]pyrene.Chlorophyllinalsodecreasescarcinogenesis,mortality,andtumornumberinanimalmodelsofDBP-inducedcarcinogenesis.
References
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