Cisplatinisaplatinum-basedcross-linkingagentthatexhibitsanticancerchemotherapeuticactivity.CisplatininducescrosslinksbetweenguaninebasesonDNA;itisclinicallyusedtotreatvariousformsofcancer.Inlungcancercells,cisplatindecreasesphosphorylationofPI3K,Akt,andFOXO3aandinducesapoptosis.Additionally,cisplatinmodulatesSTATsignalingandimmuneresponsesinothermodels.
| CasNo. | 15663-27-1 |
|---|---|
| Purity | ≥98% |
| Formula | Cl2H6N2Pt |
| FormulaWt. | 300.04 |
| ChemicalName | cis-Dichlorodiammineplatinum(II) |
| Synonym | |
| MeltingPoint | 270°C(dec.) |
| Solubility | Slightlysolubleinwater.DMSOto60mg/mL |
| Appearance | Glassyyellowororange,yellowcrystallinepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | C3374MSDSPDF |
|---|---|
| InfoSheet | C3374InfoSheetPDF |
HatoSV,KhongA,deVriesIJ,etal.Molecularpathways:theimmunogeniceffectsofplatinum-basedchemotherapeutics.ClinCancerRes.2014Jun1;20(11):2831-7.PMID:24879823.
LiuH,YinJ,WangC,etal.FOXO3amediatesthecytotoxiceffectsofcisplatininlungcancercells.AnticancerDrugs.2014Sep;25(8):898-907.PMID:24814195.
StordalB,DaveyM.Understandingcisplatinresistanceusingcellularmodels.IUBMBLife.2007Nov;59(11):696-9.PMID:17885832.
MarconL,ZhangX,HalesBF,etal.Effectsofchemotherapeuticagentsfortesticularcanceronratspermatogonialstem/Progenitorcells.JAndrol.2011Jul-Aug;32(4):432-443.PMID:21088230.
