CrenolanibisaninhibitorofFLT3andPDGFRthatexhibitsanticancerchemotherapeuticactivity.Crenolanibinhibitscellproliferationandinducesapoptosisinnon-smallcelllungcancer(NSCLC)andacutemyelogenousleukemia(AML)cells.InanimalmodelsofNSCLC,crenolanibinhibitstumorgrowth.
| CasNo. | 670220-88-9 |
|---|---|
| Purity | ≥98% |
| Formula | C26H29N5O2 |
| FormulaWt. | 443.54 |
| Synonym | CP-868596 |
| Appearance | Offwhitetofaintyellowpowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | C6818InfoSheetPDF |
|---|
WangP,SongL,GeH,etal.Crenolanib,aPDGFRinhibitor,suppresseslungcancercellproliferationandinhibitstumorgrowthinvivo.OncoTargetsTher.2014Sep26;7:1761-8.PMID:25328409.
SmithCC,LasaterEA,LinKC,etal.CrenolanibisaselectivetypeIpan-FLT3inhibitor.ProcNatlAcadSciUSA.2014Apr8;111(14):5319-24.PMID:24623852.
ZimmermanEI,TurnerDC,BuaboonnamJ,etal.Crenolanibisactiveagainstmodelsofdrug-resistantFLT3-ITD-positiveacutemyeloidleukemia.Blood.2013Nov21;122(22):3607-15.PMID:24046014.
