CYT-387(momelotinib)isaninhibitorofJAK2currentlyunderinvestigationasapotentialtreatmentformyeloproliferativeneoplasms;itdisplaysanticancerchemotherapeuticactivity.Incellularmodelsofmultiplemyeloma,momelotinibinducesG2/Mphasecellcyclearrest.Invivo,thiscompounddecreasestumorburden.
| CasNo. | 1056634-68-4 |
|---|---|
| Purity | ≥98% |
| Formula | C23H22N6O2 |
| FormulaWt. | 414.46 |
| Synonym | CYT387,CYT11387,Momelotinib |
| Appearance | Yellowtolightorangepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | C9876InfoSheetPDF |
|---|
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GeyerHL,TibesR,MesaRA.JAK2inhibitorsandtheirimpactinmyeloproliferativeneoplasms.Hematology.2012Apr;17Suppl1:S129-32.PMID:22507800.
MonaghanKA,KhongT,BurnsCJ,etal.ThenovelJAKinhibitorCYT387suppressesmultiplesignallingpathways,preventsproliferationandinducesapoptosisinphenotypicallydiversemyelomacells.Leukemia.2011Dec;25(12):1891-9.PMID:21788946.
