Oxaliplatinisaplatinum-basedcross-linkingagentthatexhibitsanticancerchemotherapeuticactivity.OxaliplatininhibitsDNAreplicationandtranscriptionandisclinicallyusedtotreatcoloncancer.Inhepatocellularcarcinomacells,oxaliplatininducesSphasecellcyclearrest,downregulatesexpressionofCDK4andcyclinD1,upregulatesexpressionofp21andp53,andinhibitscellularproliferation.
| CasNo. | 61825-94-3 |
|---|---|
| Purity | ≥98% |
| Formula | C8H14N2O4Pt |
| FormulaWt. | 397.29 |
| ChemicalName | (SP-4-2)-[(1R,2R)-1.2-Cyclohexanediamine-κN,κN"]-[ethanedioato(2-)-κO1,κO2]platinum |
| Synonym | Oxalatoplatin;Oxalatoplatinum |
| MeltingPoint | 260°C |
| Solubility | Solubleinwater(10mM,4mg/mL),DMSO(50mMor20mg/mL). |
| Appearance | WhiteCrystallinepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | O9201MSDSPDF |
|---|---|
| InfoSheet | O9201InfoSheetPDF |
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GaoJ,WangR,YangQ,etal.EffectofOxaliplatinoncellcycleofhepatocellularcarcinomacelllineHepG2.ZhejiangDaXueXueBaoYiXueBan.2013Jul;42(4):437-42.PMID:24022933.
GrahamJ,MushinM,KirkpatrickP.Oxaliplatin.NatRevDrugDiscov.2004Jan;3(1):11-2.PMID:14756144.
