PalbociclibisanorallybioavailableselectiveinhibitorofCDK4andCDK6,kinasesthatregulatecellcycleprogression.Thiscompoundexhibitsanticancerchemotherapeuticactivityinavarietyofmodels,includingrenalcellcarcinomaandER+breastcancer.Palbociclibinhibitsretinoblastomaphosphorylation,preventingcellsfromprogressingfromtheG1phasetotheSphaseandinducingapoptosis.
| CasNo. | 827022-32-2 |
|---|---|
| Purity | ≥99% |
| Formula | C24H29N7O2•HCl |
| FormulaWt. | 483.99 |
| IUPACName | 6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one;hydrochloride |
| Synonym | PD-0332991 |
| Solubility | SolubleinDMSOandwater |
| Appearance | YellowPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P0244InfoSheetPDF |
|---|
LoganJE,MostofizadehN,DesaiAJ,etal.PD-0332991,aPotentandSelectiveInhibitorofCyclin-dependentKinase4/6,DemonstratesInhibitionofProliferationinRenalCellCarcinomaatNanomolarConcentrationsandMolecularMarkersPredictforSensitivity.AnticancerRes.2013Aug;33(8):2997-3004.PMID:23898052.
RobertsPJ,BisiJE,StrumJC,etal.Multiplerolesofcyclin-dependentkinase4/6inhibitorsincancertherapy.JNatlCancerInst.2012Mar21;104(6):476-87.PMID:22302033.
RivadeneiraDB,MayhewCN,ThangavelC,etal.ProliferativesuppressionbyCDK4/6inhibition:complexfunctionoftheretinoblastomapathwayinlivertissueandhepatomacells.Gastroenterology.2010May;138(5):1920-30.PMID:20100483.
