LKT/PEMETREXED DISODIUM/P1849/100 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/PEMETREXED DISODIUM/P1849/100 mg

LKT/PEMETREXED DISODIUM/P1849/100 mg

商品编号： P1849-100mg

品牌： lktlabs

市场价： ¥1660.00

美元价： 996.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDP1849

CasNo.150399-23-8

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Pemetrexedisanantifolateanticancerchemotherapeuticthatinhibitsthymidylatesynthase.Pemetrexediscurrentlyinclinicaltrialsasapotentialtreatmentforovariancancerandlungadenocarcinoma.Pemetrexedmayalsoinhibitotherenzymesinvolvedinfolatemetabolism,includingserinehydroxymethyltransferase(SHMT),dihydrofolatereductase(DHFR),andglycinamideribonucleotideformyltransferase(GARFT).Invitro,Pemetrexedinducesactivationofcaspases2,3,8,and9andincreaseslevelsofBax,Fas,deathreceptor4(DR4),anddeathreceptor5(DR5),resultingincaspase-mediatedapoptosis.

ProductInfo

CasNo.	150399-23-8
Purity	≥98%
Formula	C₂₀H₁₉N₅Na₂O₆
FormulaWt.	471.37
IUPACName	disodium;(2S)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate
Solubility	Water
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

MSDS	P1849MSDSPDF
InfoSheet	P1849InfoSheetPDF

References

WaltersCL,ArendRC,ArmstrongDK,etal.FolateandfolatereceptoralphaantagoNISTsmechanismofactioninovariancancer.GynecolOncol.2013Nov;131(2):493-8.PMID:23863359.

LauDH,MoonJ,DaviesAM,etal.SouthwesternoncologygroupphaseIItrial(S0526)ofpemetrexedinbronchioloalveolarcarcinomasubtypesofadvancedadenocarcinoma.ClinLungCancer.2013Jul;14(4):351-5.PMID:23415808.

YangTY,ChangGC,ChenKC,etal.Pemetrexedinducesbothintrinsicandextrinsicapoptosisthroughataxiatelangiectasiamutated/p53-dependentand-independentsignalingpathways.MolCarcinog.2013Mar;52(3):183-94.PMID:22086658.

SuL,LiuG,HaoX,etal.Deathreceptor5andcellularFLICE-inhibitoryproteinregulatepemetrexed-inducedapoptosisinhumanlungcancercells.EurJCancer.2011Nov;47(16):2471-8.PMID:21726997.

DaidoneF,FlorioR,RinaldoS,etal.Insilicoandinvitrovalidationofserinehydroxymethyltransferaseasachemotherapeutictargetoftheantifolatedrugpemetrexed.EurJMedChem.2011May;46(5):1616-21.PMID:21371789.

JoergerM,OmlinA,CernyT,etal.Theroleofpemetrexedinadvancednonsmall-celllungcancer:specialfocusonpharmacologyandmechanismofaction.CurrDrugTargets.2010Jan;11(1):37-47.PMID:19839929.

BlackwoodE,EplerJ,YenI,etal.Combinationdrugschedulingdefinesa“windowofopportunity”forchemopotentiationofgemcitABInebyanorallybioavailable,selectiveChK1inhibitor,GNE-900.MolCancerTher.2013Oct;12(10):1968-1980.PMID:23873850.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂