Perifosineisanalkylphospholipidanalogthatexhibitsanticancerchemotherapeuticandanti-inflammatoryactivities.PerifosinedirectlyinhibitsAktbybindingatmultiplesites.Inmacrophages,perifosineinhibitsLPS-inducedincreasesinTNF-αandERKactivationandactivatesAMPK.Incolorectalcancer,hepatocellularcarcinoma,andmultiplemyelomacells,perifosineinducesapoptosisandinhibitsgrowth;inclinicalsettings,perifosineenhancestheanticanceractivityofotherchemotherapeutics.
| CasNo. | 157716-52-4 |
|---|---|
| Purity | ≥98% |
| Formula | C25H52NO4P |
| FormulaWt. | 461.66 |
| IUPACName | (1,1-dimethylpiperidin-1-ium-4-yl)octadecylphosphate |
| Synonym | KRX-0401 |
| Appearance | WhiteCrystalPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P1969InfoSheetPDF |
|---|---|
| Brochures | PI3K-Akt-mTORCPathwayBooklet |
GradzielCS,WangY,StecB,etal.CytotoxicamphiphilesandphosphoinositidesbindtotwodiscretesitesontheAkt1PHdomain.Biochemistry.2014Jan28;53(3):462-72.PMID:24383815.
ShenJ,LiangL,WangC.Perifosineinhibitslipopolysaccharide(LPS)-inducedtumornecrosisfactor(TNF)-αproductionviaregulationmultiplesignalingpathways:newimplicationforKawasakidisease(KD)treatment.BiochemBiophysResCommun.2013Jul26;437(2):250-5.PMID:23806687.
RichardsonPG,EngC,KolesarJ,etal.Perifosine,anoral,anti-canceragentandinhibitoroftheAktpathway:mechaNISTicactions,pharmacodynamics,pharmacokinetics,andclinicalactivity.ExpertOpinDrugMetabToxicol.2012May;8(5):623-33.PMID:22512706.
FeiHR,ChenG,WangJM,etal.PerifosineinducescellcyclearrestandapoptosisinhumanhepatocellularcarcinomacelllinesbyblockadeofAktphosphorylation.Cytotechnology.2010Oct;62(5):449-60.PMID:20842425.
