PF-04217903isatriazolopyrazineinhibitorofc-METthatdisplaysanticancerchemotherapeuticandanti-metastaticactivities.PF-04217903inhibitscellproliferation,invasion,andmigrationaswellastumorgrowthinvariouscancermodels.Inanimalmodelsofpancreaticneuroendocrinetumors,thiscompoundpreventslymphnodemetastasis.
| CasNo. | 1159490-85-3 |
|---|---|
| Purity | ≥98% |
| Formula | C19H16N8O |
| FormulaWt. | 372.38 |
| IUPACName | 2-{4-[1-(6-Quinolinylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazol-1-yl}ethanol |
| Synonym | PF04217903 |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | P2012InfoSheetPDF |
|---|
SenninoB,Ishiguro-OonumaT,SchriverBJ,etal.Inhibitionofc-MetreduceslymphaticmetastasisinRIP-Tag2transgenicmice.CancerRes.2013Jun15;73(12):3692-703.PMID:23576559.
ZouHY,LiQ,LeeJH,etal.SensitivityofselectedhumantumormodelstoPF-04217903,anovelselectivec-Metkinaseinhibitor.MolCancerTher.2012Apr;11(4):1036-47.PMID:22389468.
TimofeevskiSL,McTigueMA,RyanK,etal.Enzymaticcharacterizationofc-Metreceptortyrosinekinaseoncogenicmutantsandkineticstudieswithaminopyridineandtriazolopyrazineinhibitors.Biochemistry.2009Jun16;48(23):5339-49.PMID:19459657.
