Description
Phorbol-12-myristate-13-acetate (PMA) activates PKC and induces DNA damage. PMA exhibits pro-inflammatory, carcinogenic, and cytotoxic activities. This compound is often used in research models as a tumor promoter.
LKT/PHORBOL-12-MYRISTATE-13-ACETATE/P2857/1 mg
市场价：
¥1720.00
美元价：
1032.00
产品分类：
临床研究
公司分类：
clinical_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product ID P2857
Cas No. 16561-29-8
Purity ≥98%
- Description
- Product Info
- Shipping and Storage
- Downloads
- References
Product Info
| Cas No. | 16561-29-8 |
|---|---|
| Purity | ≥98% |
| Formula | C36H56O8 |
| Formula Wt. | 616.84 |
| Chemical Name | 12-Tetradecanoyl phorbol-13-acetate |
| Synonym | TPA; PMA; Tetradecanoylphorbol acetate; 4beta-Phorbol 12-myristate 13-acetate; Phorbol ester |
| Melting Point | 50-70°C |
| Solubility | Soluble in DMSO, methanol, ethanol, ethyl acetate, or chloroform. Insoluble in water or aqueous buffer |
| Appearance | Colorless Liquid |
Shipping and Storage
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
Downloads
| MSDS | P2857 MSDS PDF |
|---|---|
| Info Sheet | P2857 Info Sheet PDF |
References
Poachanukoon O, Koontongkaew S, Monthanapisut P, et al. Macrolides attenuate phorbol ester-induced tumor necrosis factor-α and mucin production from human airway epithelial cells. Pharmacology. 2014;93(1-2):92-9. PMID: 24556631.
Oskoueian E, Abdullah N, Ahmad S. Phorbol esters isolated from Jatropha meal induced apoptosis-mediated inhibition in proliferation of chang and Vero cell lines. Int J Mol Sci. 2012 Oct 24;13(11):13816-29. PMID: 23203036.
Colombo D, Tringali C, Franchini L, et al. Glycoglycerolipid analogues inhibit PKC translocation to the plasma membrane and downstream signaling pathways in PMA-treated fibroblasts and human glioblastoma cells, U87MG. Eur J Med Chem. 2011 May;46(5):1827-34. PMID: 21388717.
Birnboim HC. Factors which affect DNA strand breakage in human leukocytes exposed to a tumor promoter, phorbol myristate acetate. Can J Physiol Pharmacol. 1982 Nov;60(11):1359-66. PMID: 6295575.
品牌介绍
LKT Labs
LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。
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