Description
Cycloheptylaminomethylenediphosphateisabisphosphonatecompoundthatinhibitssqualenesynthaseandsterolbiosynthesisinvitroandinvivo.Invariousimmunecells,thiscompoundincreasescaspase-mediatedapoptosis.Likeotherbisphosphonates,thiscompoundisknownforitsuseinpreventingboneresorptionandboneloss.Invivo,thiscompoundinhibitsosteoclast-mediatedboneresorptionandpreventsbonelossduetoimmobilization.WhenadmiNISTeredchronically,thiscompounddelaysfracturehealinginvivo,butimprovesstiffnessandultimateloadofthefracturedbone;itdoesnotpreventboneformation.
References
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