Description
Ecdysterone is a steroid hormone initially produced by arthropods that controls ecdysis and metamorphosis. Ecdysterone binds the ecdysone receptor. This compound induces autophagy and caspase activity during larval-prepupal transition periods in Drosophila. In mammals, ecdysterone may exhibit anabolic activity, decreasing chronic fatigue of nerves and muscles. Ecdysterone may also exhibit pro-angiogenic activity, increasing microvessel density and enhancing angiogenesis in models of cerebral ischemia.
References
Liu H, Jia Q, Tettamanti G, et al. Balancing crosstalk between 20-hydroxyecdysone-induced autophagy and caspase activity in the fat body during Drosophila larval-prepupal transition. Insect Biochem Mol Biol. 2013 Nov;43(11):1068-78. PMID: 24036278.
Volodin VV, Sidorova IuS, Mazo VK. 20-Hydroxyecdysone--plant adaptogen: an anabolic effect, possible use in sports nutrition. Vopr Pitan. 2013;82(6):24-30. PMID: 24741953.
Luo C, Yi B, Fan W, et al. Enhanced angiogenesis and astrocyte activation by ecdysterone treatment in a focal cerebral ischemia rat model. Acta Neurochir Suppl. 2011;110(Pt 1):151-5. PMID: 21116931.
