Ecdysteroneisasteroidhormoneinitiallyproducedbyarthropodsthatcontrolsecdysisandmetamorphosis.Ecdysteronebindstheecdysonereceptor.Thiscompoundinducesautophagyandcaspaseactivityduringlarval-prepupaltransitionperiodsinDrosophila.Inmammals,ecdysteronemayexhibitanabolicactivity,decreasingchronicfatigueofnervesandmuscles.Ecdysteronemayalsoexhibitpro-angiogenicactivity,increasingmicrovesseldensityandenhancingangiogenesisinmodelsofcerebralischemia.
| CasNo. | 5289-74-7 |
|---|---|
| Purity | ≥96% |
| Formula | C27H44O7 |
| FormulaWt. | 480.64 |
| ChemicalName | (2β,3β,5β,22R)-2,3,14,20,22,25-Hexahydroxycholest-7-en-6-one |
| IUPACName | (2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-17-[(2R,3R)-2,3,6-trihydroxy-6-methylheptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one |
| Synonym | 20-Hydroxyecdysone;Crustecdysone;Isoinokosterone;PolypodineA |
| MeltingPoint | 242-244°C |
| Solubility | Solubleinalcohol. |
| Appearance | WhitePowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | E0813MSDSPDF |
|---|---|
| InfoSheet | E0813InfoSheetPDF |
LiuH,JiaQ,TettamantiG,etal.Balancingcrosstalkbetween20-hydroxyecdysone-inducedautophagyandcaspaseactivityinthefatbodyduringDrosophilalarval-prepupaltransition.InsectBiochemMolBiol.2013Nov;43(11):1068-78.PMID:24036278.
VolodinVV,SidorovaIuS,MazoVK.20-Hydroxyecdysone--plantadaptogen:ananaboliceffect,possIBLeuseinsportsnutrition.VoprPitan.2013;82(6):24-30.PMID:24741953.
LuoC,YiB,FanW,etal.Enhancedangiogenesisandastrocyteactivationbyecdysteronetreatmentinafocalcerebralischemiaratmodel.ActaNeurochirSuppl.2011;110(Pt1):151-5.PMID:21116931.
