Description
EstrADIolisanendogenousestrogenicsteroidhormonecommonlyusedinoralcontraceptivesandhormonereplacementtherapy(HRT).Estradiolregulatesestrousandmenstrualreproductivecycles,inducesgrowthinreproductiveorgans,andincreasessecretionofluteinizinghormone(LH).Estradiolinhibitsacetylcholine-inducedvascularconstrictioninpost-menopausalwomenandinhibitsspermapoptosisinvitro.Estradioldisplayssomeadditionalanticancerpotential,inhibitinggrowthandproliferationofprostatecancercells.Estradiolalsoexhibitsantioxidativebenefit,inhibitingoxidativestress-inducedcelldeathanddamageandinhibitingglutamate-inducedneurotoxicity.
References
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BehlC,WidmannM,TrappT,etal.17-betaestradiolprotectsneuronsfromoxidativestress-inducedcelldeathinvitro.BiochemBiophysResCommun.1995Nov13;216(2):473-82.PMID:7488136.
CollinsP,RosanoGM,SarrelPM,etal.17beta-Estradiolattenuatesacetylcholine-inducedcoronaryarterialconstrictioninwomenbutnotmenwithcoronaryheartdisease.Circulation.1995Jul1;92(1):24-30.PMID:7788912.
CarrubaG,PfefferU,FecarottaE,etal.Estradiolinhibitsgrowthofhormone-nonresponsivePC3humanprostatecancercells.CancerRes.1994Mar1;54(5):1190-3.PMID:8118804.