LKT/依托泊苷/E7657/500 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/依托泊苷/E7657/500 mg

LKT/依托泊苷/E7657/500 mg

商品编号： E7657-500mg

品牌： lktlabs

市场价： ¥4960.00

美元价： 2976.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Product ID E7657

Cas No. 33419-42-0

Purity ≥98%

Description
Product Info
Shipping and Storage
Downloads
References

Description

Etoposide is a derivative of epipodophyllotoxin that acts as an anticancer chemotherapeutic and immunomodulatory compound, inhibiting DNA topoisomerase II and preventing DNA repair. In breast cancer cells, etoposide increases phosphorylation of p38 MAPK and CHK2 and decreases expression of fragile histidin triad (FHIT), causing cell death. In hepatoma cells, etoposide induces mixed modes of programmed cell death, including both autophagy and apoptosis. In leukemia cells, etoposide increases transcription of PKCδ. Etoposide is also used to treat hemophagocytic lymphohistiocytosis (HLH), in which it decreases release of pro-inflammatory cytokines and inhibits activated T cells, increasing survival rates. Semi-synthetic material. Epipodophyllotoxin from podophyllum versipelle Hance.

Product Info

Cas No.	33419-42-0
Purity	≥98%
Formula	C₂₉H₃₂O₁₃
Formula Wt.	588.56
Chemical Name	9-[(4,6-O-Ethylidene-β-D-glucopyranosyl)oxy]-5,8,- 8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)- furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
IUPAC Name	(5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
Synonym	EPEG; Lastet; Vepesid
Melting Point	236-251°C, 265-270°C
Solubility	Slightly soluble in ethanol or chloroform. Practically insoluble in water.
Appearance	White Crystal Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	E7657 MSDS PDF
Info Sheet	E7657 Info Sheet PDF

References

Johnson TS, Terrell CE, Millen SH, et al. Etoposide selectively ablates activated T cells to control the immunoregulatory disorder hemophagocytic lymphohistiocytosis. J Immunol. 2014 Jan 1;192(1):84-91. PMID: 24259502.

Mir Mohammadrezaei F, Mohseni kouchesfehani H, Montazeri H, et al. Signaling crosstalk of FHIT, CHK2 and p38 in etoposide induced growth inhibition in MCF-7 cells. Cell Signal. 2013 Jan;25(1):126-32. PMID: 23000346.

Yoo SH, Yoon YG, Lee JS, et al. Etoposide induces a mixed type of programmed cell death and overcomes the resistance conferred by Bcl-2 in Hep3B hepatoma cells. Int J Oncol. 2012 Oct;41(4):1443-54. PMID: 22895528.

Shin SY, Kim CG, Ko J, et al. Transcriptional and post-transcriptional regulation of the PKC delta gene by etoposide in L1210 murine leukemia cells: implication of PKC delta autoregulation. J Mol Biol. 2004 Jul 16;340(4):681-93. PMID: 15223313.

Mizumoto K, Rothman RJ, Farber JL. Programmed cell death (apoptosis) of mouse fibroblasts is induced by the topoisomerase II inhibitor etoposide. Mol Pharmacol. 1994 Nov;46(5):890-5. PMID: 7969076.

Nissen NI, Dombernowsky P, Hansen HH, et al. The epipodophyllotoxin derivatives VM-26 and VP-16-213, 1976-1979, a review. Recent Results Cancer Res. 1980;74:98-106. PMID: 7003663.

Marcon L, Zhang X, Hales BF, et al. Effects of chemotherapeutic agents for testicular cancer on rat spermatogonial stem/progenitor cells. J Androl. 2011 Jul-Aug;32(4):432-443. PMID: 21088230.

Li Z, Sun B, Clewell RA, et al. Dose-response modeling of etoposide-induced DNA damage response. Toxicol Sci. 2014 Feb;137(2):371-384. PMID: 24241721.

Zhang F, Koh GY, Hollingsworth J, et al. Reformulation of etoposide with solubility-enhancing rubusoside. Int J Pharm. 2012 Sep 15;434(1-2):453-459. PMID: 22698860.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂