LKT/ETOPOSIDE PHOSPHATE/E7658/25 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/ETOPOSIDE PHOSPHATE/E7658/25 mg

LKT/ETOPOSIDE PHOSPHATE/E7658/25 mg

商品编号： E7658-25mg

品牌： lktlabs

市场价： ¥1840.00

美元价： 1104.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDE7658

CasNo.117091-64-2

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Etoposideisaderivativeofepipodophyllotoxinthatactsasananticancerchemotherapeuticandimmunomodulatorycompound,inhibitingDNAtopoisomeraseIIandpreventingDNArepair.Inbreastcancercells,etoposideincreasesphosphorylationofp38MAPKandCHK2anddecreasesexpressionoffragilehistidintriad(FHIT),causingcelldeath.Inhepatomacells,etoposideinducesmixedmodesofprogrammedcelldeath,includingbothautophagyandapoptosis.Inleukemiacells,etoposideincreasestranscriptionofPKCδ.Etoposideisalsousedtotreathemophagocyticlymphohistiocytosis(HLH),inwhichitdecreasesreleaseofpro-inflammatorycytokinesandinhibitsactivatedTcells,increasingsurvivalrates.

ProductInfo

CasNo.	117091-64-2
Purity	≥98%
Formula	C₂₉H₃₃O₁₆P
FormulaWt.	668.54
IUPACName	[4-[(5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-8-oxo-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-9-yl]-2,6-dimethoxyphenyl]dihydrogenphosphate
Synonym	Eposin,Etopophos,Vepesid,VP-16
MeltingPoint	180-183°C
Solubility	Solubleinwater
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

InfoSheet	E7658InfoSheetPDF

References

JohnsonTS,TerrellCE,MillenSH,etal.EtoposideselectivelyablatesactivatedTcellstocontroltheimmunoregulatorydisorderhemophagocyticlymphohistiocytosis.JImmunol.2014Jan1;192(1):84-91.PMID:24259502.

MirMohammadrezaeiF,MohsenikouchesfehaniH,MontazeriH,etal.SignalingcrosstalkofFHIT,CHK2andp38inetoposideinducedgrowthinhibitioninMCF-7cells.CellSignal.2013Jan;25(1):126-32.PMID:23000346.

YooSH,YoonYG,LeeJS,etal.EtoposideinducesamixedtypeofprogrammedcelldeathandovercomestheresistanceconferredbyBcl-2inHep3Bhepatomacells.IntJOncol.2012Oct;41(4):1443-54.PMID:22895528.

ShinSY,KimCG,KoJ,etal.Transcriptionalandpost-transcriptionalregulationofthePKCdeltagenebyetoposideinL1210murineleukemiacells:implicationofPKCdeltaautoregulation.JMolBiol.2004Jul16;340(4):681-93.PMID:15223313.

MizumotoK,RothmanRJ,FarberJL.Programmedcelldeath(apoptosis)ofmousefibroblastsisinducedbythetopoisomeraseIIinhibitoretoposide.MolPharmacol.1994Nov;46(5):890-5.PMID:7969076.

NissenNI,DombernowskyP,HansenHH,etal.TheepipodophyllotoxinderivativesVM-26andVP-16-213,1976-1979,areview.RecentResultsCancerRes.1980;74:98-106.PMID:7003663.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂