LKT/EVEROLIMUS/E8419/1 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/EVEROLIMUS/E8419/1 mg

LKT/EVEROLIMUS/E8419/1 mg

商品编号： E8419-1mg

品牌： lktlabs

市场价： ¥880.00

美元价： 528.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDE8419

CasNo.159351-69-6

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Everolimusisaninhibitorofmammaliantargetofrapamycin1(mTOR1)thatisusedclinicallyforitsimmunosuppressiveactivityinrenaltransplantrecipientsandiscurrentlyinclinicaltrialsexploringitsanticancerchemotherapeuticactivity.Innasopharyngealcarcinomacells,everolimusinducesapoptosisandautophagy,inhibitingcellgrowth.Inesophagealcancercells,everolimusdecreasesexpressionofmTORtargetsp70S6KandS6,increasingcelldamageanddecreasingcellproliferation.Inanimalmodelsofexperimentalautoimmuneuveoretinitis(EAU),everolimusdecreaseslevelsofTh1,Th4,andTh17cytokinesandincreaseslevelsofTregcells,attenuatingdiseasepathology.Additionally,everolimusexhibitsnephroprotectivebenefitatlowdoses,decreasingadriamycin-inducedproteinuriaandimprovingrenalfunctioninanimalmodelsofnephroticsyndrome.

ProductInfo

CasNo.	159351-69-6
Purity	≥98%
Formula	C₅₃H₈₃NO₁₄
FormulaWt.	958.22
Synonym	Certican
MeltingPoint	95-110°C
Solubility	Insolubleinwater.SolubleinDMSO(30mg/mL),ethanol(7mg/mL).
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	E8419MSDSPDF
InfoSheet	E8419InfoSheetPDF
Brochures	PI3K-Akt-mTORCPathwayBooklet

References

SendurMA,ZenginN,AksoyS,etal.Everolimus:anewhopeforpatientswithbreastcancer.CurrMedResOpin.2014Jan;30(1):75-87.PMID:24050600.

CaiY,XiaQ,SuQ,etal.mTORinhibitorRAD001(everolimus)inducesapoptotic,notautophagiccelldeath,inhumannasopharyngealcarcinomacells.IntJMolMed.2013Apr;31(4):904-12.PMID:23426850.

HennigM,BauerD,WasmuthS,etal.Everolimusimprovesexperimentalautoimmuneuveoretinitis.ExpEyeRes.2012Dec;105:43-52.PMID:23059401.

RamadanR,FaourD,AwadH,etal.Earlytreatmentwitheverolimusexertsnephroprotectiveeffectinratswithadriamycin-inducednephroticsyndrome.NephrolDialTransplant.2012Jun;27(6):2231-41.PMID:22036940.

WangZG,FukazawaT,NishikawaT,etal.RAD001offersatherapeuticinterventionthroughinhibitionofmTORasapotentialstrategyforesophagealcancer.OncolRep.2010Apr;23(4):1167-72.PMID:20204306.

KahanBD,KochSM.Currentimmunosuppressantregimens:considerationsforcriticalcare.CurrOpinCritCare.2001Aug;7(4):242-50.PMID:11571421.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂