ExemestaneisathirdgenerationaromataseinhibitorthatpreventsestrogensynthesisandisclinicallyusedtotreatER+breastcancer.Exemestaneexhibitsanticancerchemotherapeuticactivity,inhibitingproliferationandinducingcellcyclearrest,apoptosis,andautophagyinbreastcancercells.
| CasNo. | 107868-30-4 |
|---|---|
| Purity | ≥98% |
| Formula | C20H24O2 |
| FormulaWt. | 296.40 |
| ChemicalName | 6-Methyleneandrosta-1,4-diene-3,17-dione |
| IUPACName | (8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,17-dione |
| Synonym | Aromasin;FCE-24304 |
| MeltingPoint | 188-191°C |
| Solubility | Solubleinmethanol,ethanol(15mg/mL),DMSO(54mg/mL)ordimethylformamide.Insolubleinwater. |
| Appearance | Yellowishtooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | E9317MSDSPDF |
|---|---|
| InfoSheet | E9317InfoSheetPDF |
AmaralC,BorgesM,MeloS,etal.Apoptosisandautophagyinbreastcancercellsfollowingexemestanetreatment.PLoSOne.2012;7(8):e42398.PMID:22912703.
HongY,RashidR,ChenS.Bindingfeaturesofsteroidalandnonsteroidalinhibitors.Steroids.2011Jul;76(8):802-6.PMID:21420422.
BertelliG,HallE,IrelandE,etal.Long-termendometrialeffectsinpostmenopausalwomenwithearlybreastcancerparticipatingintheIntergroupExemestaneStudy(IES)--arandomisedcontrolledtrialofexemestaneversuscontinuedtamoxifenafter2-3yearstamoxifen.AnnOncol.2010Mar;21(3):498-505.PMID:19717534.
