Description
Exemestane is a third generation aromatase inhibitor that prevents estrogen synthesis and is clinically used to treat ER+ breast cancer. Exemestane exhibits anticancer chemotherapeutic activity, inhibiting proliferation and inducing cell cycle arrest, apoptosis, and autophagy in breast cancer cells.
References
Amaral C, Borges M, Melo S, et al. Apoptosis and autophagy in breast cancer cells following exemestane treatment. PLoS One. 2012;7(8):e42398. PMID: 22912703.
Hong Y, Rashid R, Chen S. Binding features of steroidal and nonsteroidal inhibitors. Steroids. 2011 Jul;76(8):802-6. PMID: 21420422.
Bertelli G, Hall E, Ireland E, et al. Long-term endometrial effects in postmenopausal women with early breast cancer participating in the Intergroup Exemestane Study (IES)--a randomised controlled trial of exemestane versus continued tamoxifen after 2-3 years tamoxifen. Ann Oncol. 2010 Mar;21(3):498-505. PMID: 19717534.