Fluocinolone is a synthetic hydrocortisone derivative that exhibits anti-inflammatory and anti-pruritic activities. Fluocinolone is a corticosteroid that is clinically used to treat ocular inflammation. In dental pulp cells, fluocinolone downregulates expression of pro-inflammatory cytokines and upregulates expression of PPARγ.
| Cas No. | 67-73-2 |
|---|---|
| Purity | ≥98% |
| Formula | C24H30F2O6 |
| Formula Wt. | 452.49 |
| Chemical Name | (6α,11β,16α)-6,9-Difluoro-11,21-dihydroxy-16,17- [(91-methylethylidene)bis(oxy)]-pregna-1,4-diene- 3,20-dione |
| Synonym | Coriphate; Dermalar; Fluonid; Fluvean; Jellin; Synalar; Synemol; Synsac |
| Melting Point | 265-266°C |
| Solubility | Slightly soluble in water (<1 mg/ml).="" ethanol="" (22=""> |
| Appearance | White/Almost White crystalline powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | F4582 MSDS PDF |
|---|---|
| Info Sheet | F4582 Info Sheet PDF |
Cunha-Vaz J, Ashton P, Iezzi R, et al. Sustained Delivery Fluocinolone Acetonide Vitreous Implants: Long-Term Benefit in Patients with Chronic Diabetic Macular Edema. Ophthalmology. 2014 Jun 13. [Epub ahead of print]. PMID: 24935282.
Liu Z, Jiang T, Wang X, et al. Fluocinolone acetonide partially restores the mineralization of LPS-stimulated dental pulp cells through inhibition of NF-κB pathway and activation of AP-1 pathway. Br J Pharmacol. 2013 Nov;170(6):1262-71. PMID: 24024985.
