Description

Flutamide is a non-steroidal inhibitor of the androgen receptor; it exhibits anticancer chemotherapeutic, anti-inflammatory, and anti-androgenic activities. Flutamide is clinically used to treat prostate cancer and polycystic ovary syndrome. In prostate cancer cells, flutamide induces S phase cell cycle arrest and inhibits cellular proliferation. Flutamide also decreases activation of NF-κB, release of pro-inflammatory cytokines, and activity of myeloperoxidase in animal models of hepatic trauma.