Flutamideisanon-steroidalinhibitoroftheandrogenreceptor;itexhibitsanticancerchemotherapeutic,anti-inflammatory,andanti-androgenicactivities.Flutamideisclinicallyusedtotreatprostatecancerandpolycysticovarysyndrome.Inprostatecancercells,flutamideinducesSphasecellcyclearrestandinhibitscellularproliferation.FlutamidealsodecreasesactivationofNF-κB,releaseofpro-inflammatorycytokines,andactivityofmyeloperoxidaseinanimalmodelsofhepatictrauma.
| CasNo. | 13311-84-7 |
|---|---|
| Purity | ≥98% |
| Formula | C11H11F3N2O3 |
| FormulaWt. | 276.22 |
| ChemicalName | 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide |
| IUPACName | 2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide |
| Synonym | Drogenil;Euflex;Flucinom;Fugerel |
| MeltingPoint | 111.5-112.5°C |
| Solubility | Insolubleinwater.SolubleinDMSO. |
| Appearance | Ayellowcrystallinepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | F4680MSDSPDF |
|---|---|
| InfoSheet | F4680InfoSheetPDF |
Al-SaeediF.Effectsofflutamideon[methyl-(3)h]-cholineuptakeinhumanprostatecancer-3cells:apilotstudy.CurrTherResClinExp.2007Jul;68(4):226-41.PMID:24683213.
ShimizuT,YuHP,HsiehYC,etal.Flutamideattenuatespro-inflammatorycytokineproductionandhepaticinjuryfollowingtrauma-hemorrhageviaestrogenreceptor-relatedpathway.AnnSurg.2007Feb;245(2):297-304.PMID:17245185.
