Description
Formestane is a steroidal androgen substrate that inhibits aromatase. Formestane is clinically used to treat ER+ breast cancer, as it inhibits production of estrogens.
Formestane is a steroidal androgen substrate that inhibits aromatase. Formestane is clinically used to treat ER+ breast cancer, as it inhibits production of estrogens.
Cas No. | 566-48-3 |
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Purity | ≥98% |
Formula | C19H26O3 |
Formula Wt. | 302.41 |
Chemical Name | 4-Hydroxyandrost-4-ene-3,17-dione |
IUPAC Name | (8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione |
Synonym | 4-OHA; Lentaron |
Melting Point | 199-202°C |
Solubility | Soluble in methanol. |
Appearance | White Crystalline Powder |
Store Temp | Ambient |
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Ship Temp | Ambient |
MSDS | F5769 MSDS PDF |
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Info Sheet | F5769 Info Sheet PDF |
Miller WR. Aromatase inhibitors: mechanism of action and role in the treatment of breast cancer. Semin Oncol. 2003 Aug;30(4 Suppl 14):3-11. PMID: 14513432.
Dowsett M. Aromatase inhibition: basic concepts, and the pharmacodynamics of formestane. Ann Oncol. 1994;5 Suppl 7:S3-5. PMID: 7873460.