Pamidronate is a bisphosphonate that exhibits anti-resorptive and anti-osteoporotic activities. Pamidronate is clinically used to prevent injury- or chemotherapy-induced bone loss. Clinically, pamidronate increases muscle fiber, bone strength, and bone density. This compound also prevents cancer metastasis to bone tissue.
| Cas No. | 109552-15-0 |
|---|---|
| Purity | ≥98% |
| Formula | C3H9NNa2O7P2 • 5H2O |
| Formula Wt. | 369.11 |
| Chemical Name | (3-Amino-1-hydroxypropylidene)bisphosphonic acid disodium salt pentahydrate |
| IUPAC Name | disodium;[3-amino-1-hyd |
| Synonym | Pamidronic acid disodium salt pentahydrate |
| Melting Point | 300°C |
| Solubility | Soluble in water. |
| Appearance | White Crystalline Powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | P0049 MSDS PDF |
|---|---|
| Info Sheet | P0049 Info Sheet PDF |
Børsheim E, Herndon DN, Hawkins HK, et al. Pamidronate attenuates muscle loss after pediatric burn injury. J Bone Miner Res. 2014 Jun;29(6):1369-72. PMID: 24347438.
Laroche M, Livideanu C, Paul C, et al. Interferon alpha and pamidronate in osteoporosis with fracture secondary to mastocytosis. Am J Med. 2011 Aug;124(8):776-8. PMID: 21787907.
Kokufu I, Kohno N, Yamamoto M, et al. Adjuvant pamidronate therapy prevents the development of bone metastases in breast cancer patients with four or more positive nodes. Oncol Lett. 2010 Mar;1(2):247-252. PMID: 22966289.
Mawardi H, Giro G, Kajiya M, et al. A role of oral bacteria in bisphosphonate-induced osteonecrosis of the jaw. J Dent Res. 2011 Nov;90(11):1339-1345. PMID: 21921248.
