Description
GlucoraphaninisaglucosinolateoriginallyfoundincruciferousvegetablesoftheBrassicaceaefamily,suchasthedaikonrADIsh.Glucoraphaninexhibitsanti-inflammatoryandneuroprotectiveactivities.Inananimalmodelofspinalcordinjury,glucoraphanindecreaseshistologicalinflammatorydamage.Inananimalmodelofrestraintstress,thiscompounddecreasesstress-inducedproductionofTNF-αandIL-1βandalsoincreasesIL-10levels.Glucoraphanindecreasesdopaminetransporterdegradation,expressionoftyrosinehydrolase,andreleaseofIL-1βandROSaswellasapoptosisinMPTP-inducedanimalmodelsofParkinson’sdisease.Inanimalmodelsofmultiplesclerosis(experimentalautoimmuneencephalitis;EAE),glucoraphanindecreasestranslocationofNF-κB,releaseofpro-inflammatorycytokines,andapoptosis.Weightisonanhydrousbasis.
References
GaluppoM,GiacoppoS,DeNicolaGR,etal.RS-Glucoraphaninbioactivatedwithmyrosinasetreatmentcounteractsproinflammatorycascadeandapoptosisassociatedtospinalcordinjuryinanexperimentalmousemodel.JNeurolSci.2013Nov15;334(1-2):88-96.PMID:23992921.
GaluppoM,IoriR,DeNicolaGR,etal.Anti-inflammatoryandanti-apoptoticeffectsof(RS)-glucoraphaninbioactivatedwithmyrosinaseinmurinesub-acuteandacuteMPTP-inducedParkinson"sdisease.BioorgMedChem.2013Sep1;21(17):5532-47.PMID:23810671
FotiCuzzolaV,GaluppoM,IoriR,etal.Beneficialeffectsof(RS)-glucoraphaninonthetightjunctiondysfunctioninamousemodelofrestraintstress.LifeSci.2013Aug28;93(7):288-305.PMID:23871805.
GiacoppoS,GaluppoM,IoriR,etal.Protectiveroleof(RS)-glucoraphaninbioactivatedwithmyrosinaseinanexperimentalmodelofmultiplesclerosis.CNSNeurosciTher.2013Aug;19(8):577-84.PMID:23638842.
