Description
HT-2 toxin is a trichothecene mycotoxin initially produced by Fusarium and is also a metabolite of T2 toxin. HT-2 toxin is often produced in grains used as livestock feed and in the production of products for human consumption such as cereal. HT-2 toxin passes across the blood-brain barrier more easily than T2 toxin, exhibiting neurotoxicity by inducing apoptosis.
References
Ortiz J, Van Camp J, Mestdagh F, et al. Mycotoxin co-occurrence in rice, oat flakes and wheat noodles used as staple foods in Ecuador. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013 Dec 7. [Epub ahead of print]. PMID: 24313870.
Weidner M, Hüwel S, Ebert F, et al. Influence of T-2 and HT-2 toxin on the blood-brain barrier in vitro: new experimental hints for neurotoxic effects. PLoS One. 2013;8(3):e60484. PMID: 23544145.