HypaconitineisaditerpenealkaloidoriginallyfoundinAconitumthatactsasaneuromuscularjunctionblocker.Hypaconitineinhibitsendplatepotentialsinisolatedphrenicnerve-diaphragmmuscles.Hypaconitineinduceslong-termopeningofNa+channels,causingmembranedepolarizationandpreventingrepolarization.
| CasNo. | 6900-87-4 |
|---|---|
| Purity | ≥90% |
| Formula | C33H45NO10 |
| FormulaWt. | 615.71 |
| ChemicalName | 16,16-trimethoxy-4-(methoxymethyl)-20-methyl-8-acetatebenzoate-(1-alpha,6-alpha,14-alpha,15-alpha,16-beta)-Aconitane-8,13,14,15-tetraol |
| Appearance | Whitecrystallinepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | H9759MSDSPDF |
|---|---|
| InfoSheet | H9759InfoSheetPDF |
MuroiM,KimuraI,KimuraM.Blockingeffectsofhypaconitineandaconitineonnerveactionpotentialsinphrenicnerve-diaphragmmusclesofmice.Neuropharmacology.1990Jun;29(6):567-72.PMID:2385329.
KimuraM,MuroiM,KimuraI,etal.Hypaconitine,thedominantconstituentresponsIBLefortheneuromuscularblockingactionoftheJapanese-sinomedicine"bushi"(aconiteroot).JpnJPharmacol.1988Oct;48(2):290-3.PMID:3210453.
