Description
Iberinisanisothiocyanate(ITC)andsulforaphanehomologthatexhibitsantioxidativeandanticancerchemotherapeuticactivity.LikeotherITCs,iberinmaydisplaychemopreventivepotentialbyinducingphaseIIenzymes.Invitro,iberininducesNrf2nucleartranslocationandincreaseslevelsofhemeoxygenase-1andglutamylcysteinesynthetase,bothpotentiallyrelatedtoalterationsinERKsignaling.Iberinalsoincreasesexpressionofantioxidativeenzymesthioredoxinreductase1andglutathioneperoxidase2incellularmodels.Incancercells,iberininducesp21expression,decreasesexpressionofcyclin-dependentkinases(CDKs)2,4,and6,andincreasescaspaseactivity,resultinginapoptosis.
References
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