Iberverinisasulforaphanehomologfoundincruciferousvegetables.Thisisothiocyanate(ITC)exhibitsantioxidativeactivity.IberverininducesphaseIIenzymes,increasingglutathione-S-transferaseandquinonereductaseexpressioninvivo.Additionally,iberverinincreasesexpressionofNrf2,γ-glutamylcysteinesynthetase,andhemeoxygenase1(HO-1).Iberverindisplayschemopreventivepotential,decreasingexpressionofandrogenreceptors(ARs)inprostatecancercells.
| CasNo. | 505-79-3 |
|---|---|
| Purity | ≥98% |
| Formula | C5H9NS2 |
| FormulaWt. | 147.26 |
| ChemicalName | 1-Isothiocyanato-3-(methylsulfenyl)-propane |
| IUPACName | 1-isothiocyanato-3-methylsulfanylpropane |
| Synonym | 1-Isothiocyanato-3-(methylthio)propane;3-Methyl-mercaptopropylisothiocyanate;3-Methylthiopropylisothiocyanate |
| Appearance | YellowLiquid |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | I0418MSDSPDF |
|---|---|
| InfoSheet | I0418InfoSheetPDF |
ErnstIM,PalaniK,EsatbeyogluT,etal.SynthesisandNrf2-inducingactivityoftheisothiocyanatesiberverin,iberinandcheirolin.PharmacolRes.2013Apr;70(1):155-62.PMID:23403058.
KimSH,SinghSV.D,L-Sulforaphanecausestranscriptionalrepressionofandrogenreceptorinhumanprostatecancercells.MolCancerTher.2009Jul;8(7):1946-54.PMID:19584240.
MundayR,MundayCM.InductionofphaseIIdetoxificationenzymesinratsbyplant-derivedisothiocyanates:comparisonofallylisothiocyanatewithsulforaphaneandrelatedcompounds.JAgricFoodChem.2004Apr7;52(7):1867-71.PMID:15053522.
