Description
IcaritinisaflavonoidcompoundfoundinEpimediumthatexhibitsanti-inflammatory,anticancer,andantidepressantactivities;italsoactsasaphytoestrogen.Icaritinmayactthroughcorticosteroidsignaling,asitincreasesglucocorticoidreceptorandBDNFmRNAinthehippocampus.Inanimalmodelsofstress,icaritinpreventsdevelopmentofsocialavoidance.Thiscompounddecreaseslevelsofpro-inflammatorycytokinesIL-6andTNF-αaswellasPPARγ,GSK-3β,MCP-1,p38JNK,c-myc,p-ERK,andp-Akt,inhibitingcellproliferationandinducingapoptosis.Additionally,icaritinshowsbenefitasapotentialtreatmentforbonedisease,atitstimulatesosteogenicdifferentiationandinhibitsADIpogenesisinvitro.
References
WuX,WuJ,XiaS,etal.IcaritinopposesthedevelopmentofsocialaversionafterdefeatstressviaincreasesofGRmRNAandBDNFmRNAinmice.BehavBrainRes.2013Sep21;256C:602-608.PMID:24064280.
ShengH,RuiXF,ShengCJ,etal.Anovelsemisyntheticmoleculeicaritinstimulatesosteogenicdifferentiationandinhibitsadipogenesisofmesenchymalstemcells.IntJMedSci.2013Apr23;10(6):782-9.PMID:23630444.
LaiX,YeY,SunC,etal.Icaritinexhibitsanti-inflammatoryeffectsinthemouseperitonealmacrophagesandperitonitismodel.IntImmunopharmacol.2013May;16(1):41-9.PMID:23566810.
LiQ,HuaiL,ZhangC,etal.IcaritininducesAMLcellapoptosisviatheMAPK/ERKandPI3K/AKTsignalpathways.IntJHematol.2013May;97(5):617-23.PMID:23550021.
