Description
IndirubinisabisindoleisomerofindigofoundinIndigonaturalis.Indirubinexhibitsanti-inflammatory,anti-angiogenic,andanticancerchemotherapeuticactivities.Invivo,indirubindecreaseslevelsofIgEandproductionofinflammatorycytokines,decreasingoverallinflammationaswellasskinlesionthicknessandhyperkeratosis.Invitro,indirubindownregulatesexpressionofCDC25BandinhibitsEGFRandCDKs.Inleukemiacells,thiscompoundinhibitsexpressionofIAP1,IAP2,Bcl-2,Bcl-xL,TRAF1,cyclinD1,c-Myc,COX-2,andMMP-9.Inendothelialcells,indirubininhibitscellmigration,tubeformation,andsurvival;additionally,itsuppressesVEGFR2-mediatedJAK/STATsignaling.Indirubinalsoinhibitsgrowthofprostatetumorsinanimalmodels.
References
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