Description
Isoliquiritigeninisachalconewithawidevarietyoftargets;itexhibitsanticancer,anti-angiogenic,antioxidative,andneuroprotectiveactivities.IsoliquiritigenininhibitsNMDAreceptors,histonedeacetylases(HDACs),VEGFR2,andNF-κB(viainhibitionofIκBkinase).Invitro,thiscompoundincreasesNrf2expression.Additionally,isoliquiritigenindownregulatesexpressionofarachidonicacid-metabolizingenzymescyclooxygenase-2(COX-2)andphospholipaseA2(PLA2),increasingmitochondria-and/orcaspase-mediatedapoptosis,andinhibitingproliferationofbreastcancercells.IsoliquiritigeninalsomodulatessirtuinsandactsasapositiveallostericmodulatoratGABA-Areceptors.
References
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