Description
Kaempferol is a flavonol found in many plant sources that exhibits antioxidative, anti-inflammatory, neuroprotective, anti-angiogenic, anti-metastatic, anti-obesity, and anticancer chemotherapeutic activities. Kaempferol inhibits LPS-induced release of TNF-α, IL-1β, IL-6, and IL-18 as well as activation of NF-κB and Akt in vitro. In neurons, kaempferol decreases glutamate-induced increases in ROS levels and oxidative stress. In animal models of bladder cancer, this compound inhibits cell proliferation, induces apoptosis, and decreases tumor growth. In vitro, kaempferol also decreases adipogenesis, suppresses triglyceride synthesis, and increases lipolysis. Kaempferol inhibits VEGF secretion and angiogenesis in cellular models. In osteosarcoma cells, this compound inhibits cell migration by decreasing expression of uPA and matrix metalloproteinases 2 and 9 (MMP2/9).
References
Tang XL, Liu JX, Dong W, et al. Protective Effect of Kaempferol on LPS plus ATP-Induced Inflammatory Response in Cardiac Fibroblasts. Inflammation. 2014 Sep 5. [Epub ahead of print]. PMID: 25189464.
Yang EJ, Kim GS, Jun M, et al. Kaempferol attenuates the glutamate-induced oxidative stress in mouse-derived hippocampal neuronal HT22 cells. Food Funct. 2014 Jul 25;5(7):1395-402. PMID: 24770605.
Dang Q, Song W, Xu D, et al. Kaempferol suppresses bladder cancer tumor growth by inhibiting cell proliferation and inducing apoptosis. Mol Carcinog. 2014 Apr 2. [Epub ahead of print]. PMID: 24700700.
Chen HJ, Lin CM, Lee CY, et al. Kaempferol suppresses cell metastasis via inhibition of the ERK-p38-JNK and AP-1 signaling pathways in U-2 OS human osteosarcoma cells. Oncol Rep. 2013 Aug;30(2):925-32. PMID: 23708932.
Park UH, Jeong JC, Jang JS, et al. Negative regulation of adipogenesis by kaempferol, a component of Rhizoma Polygonati falcatum in 3T3-L1 cells. Biol Pharm Bull. 2012;35(9):1525-33. PMID: 22975504.
Luo H, Rankin GO, Juliano N, et al. Kaempferol inhibits VEGF expression and in vitro angiogenesis through a novel ERK-NFκB-cMyc-p21 pathway. Food Chem. 2012 Jan 15;130(2):321-328. PMID: 21927533.
