Kainicacidisanexcitatoryaminoacidoriginallyfoundinseaweed;itactivateskainatereceptorsandAMPAreceptors,increasingglutamatereleaseandstimulatingNa+channels.Kainicacidisusedinresearchmodelstoinduceseizuresduetoitsneurotoxicandepileptogenicactivities.
| CasNo. | 487-79-6 |
|---|---|
| Purity | ≥98% |
| Formula | C10H15NO4 |
| FormulaWt. | 213.23 |
| ChemicalName | [2S-(2α,3β,4β)]-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineaceticacid |
| IUPACName | (2S,3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-ylpyrrolidine-2-carboxylicacid |
| Synonym | Digenin;Helminal |
| MeltingPoint | 251°C(dec.) |
| Solubility | Solubleinwater.Insolubleinethanol. |
| Appearance | Whitetooff-whitecrystallinesolid |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | K0133MSDSPDF |
|---|---|
| InfoSheet | K0133InfoSheetPDF |
FritschB,ReisJ,GasiorM,etal.RoleofGluK1kainatereceptorsinseizures,epilepticdischarges,andepileptogenesis.JNeurosci.2014Apr23;34(17):5765-75.PMID:24760837.
Ben-AriY.KainateandTemporalLobeEpilepsies:3decadesofprogress.In:NoebelsJL,AvoliM,RogawskiMA,etal.editors.Jasper"sBasicMechanismsoftheEpilepsies[Internet].4thedition.Bethesda(MD):NationalCenterforBiotechnologyInformation(US);2012.PMID:22787646.
