Description
KenpaulloneisaninhibitorofGSK-3β,HGK,andCDKsthatexhibitsanti-inflammatory,immunomodulatory,andneuroprotectiveactivities.KenpaulloneincreaseslevelsofSREBP-1aswellasGIRK-4andacetylcholine-activatedinwardlyrectifyingK+(IKACh)channelsindiabeticmice.KenpaullonealsoinhibitsTGF-β-inducedinductionofRORγtandincreasesexpressionofFoxp3inTcells,inhibitingpathologyofexperimentalautoimmuneencephalitis(EAE)invivo.Inpluripotentstemcellsderivedfromautotrophiclateralsclerosis(ALS)patients,kenpaulloneimprovesmotorneuronsurvival.Additionally,thiscompoundinhibitsMPP+-inducedcelldeathincellularmodelsofParkinson’sdiseasebypreventingchangesinthemitochondrialmembranepotentialandinhibitingactivationofcaspases.
References
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