GW-5074isanindolethatfunctionsasahighlyselectiveRaf-1(c-Raf)kinaseinhibitorandisusedtostudyRas/Raf-1/ERKsignaling.ThiscompoundinhibitsdesuccinylationactivityofSirt5(ahistonedeacetylase),alteringDNArepairandmetabolisminvitro.GW-5074isalsoneuroprotectiveagainst6-OHDAtoxicity,whichisacommonlystudiedexperimentalmodelofParkinson’sDisease.
| CasNo. | 220904-83-6 |
|---|---|
| Purity | ≥98% |
| Formula | C15H8Br2INO2 |
| FormulaWt. | 520.94 |
| ChemicalName | 2H-Indol-2-one,3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo- |
| IUPACName | (3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one |
| Solubility | DMSO104mg/mL |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | G8850InfoSheetPDF |
|---|
SuenkelB,FischerF,SteegbornC.InhibitionofthehumandeacylaseSirtuin5bytheindoleGW5074.BioorgMedChemLett.2013Jan1;23(1):143-6.PMID:23195732.
LiJ,FanY,ZhangYN,etal.TheRaf-1inhibitorGW5074andtheERK1/2pathwayinhibitorU0126amelioratePC12cellsapoptosisinducedby6-hydroxydopamine.Pharmazie.2012Aug;67(8):718-24.PMID:22957439.
