GW-5074 is an indole that functions as a highly selective Raf-1 (c-Raf) kinase inhibitor and is used to study Ras/Raf-1/ERK signaling. This compound inhibits desuccinylation activity of Sirt5 (a histone deacetylase), altering DNA repair and metabolism in vitro. GW-5074 is also neuroprotective against 6-OHDA toxicity, which is a commonly studied experimental model of Parkinson’s Disease.
| Cas No. | 220904-83-6 |
|---|---|
| Purity | ≥98% |
| Formula | C15H8Br2INO2 |
| Formula Wt. | 520.94 |
| Chemical Name | 2H-Indol-2-one, 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo- |
| IUPAC Name | (3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one |
| Solubility | DMSO 104 mg/mL |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | G8850 Info Sheet PDF |
|---|
Suenkel B, Fischer F, Steegborn C. Inhibition of the human deacylase Sirtuin 5 by the indole GW5074. Bioorg Med Chem Lett. 2013 Jan 1;23(1):143-6. PMID: 23195732.
Li J, Fan Y, Zhang YN, et al. The Raf-1 inhibitor GW5074 and the ERK1/2 pathway inhibitor U0126 ameliorate PC12 cells apoptosis induced by 6-hydroxydopamine. Pharmazie. 2012 Aug;67(8):718-24. PMID: 22957439.
