Description
HydroxyzineisafirstgenerationantihistaminethatactsasaninverseagoNISTathistamineH1receptors.Hydroxyzineexhibitsanti-allergic,antipsychotic,anxiolytic,andsedativeactivities;itistheparentcompoundofcetirizine.Hydroxyzinealsoinhibits5-HT2A,D1/2,andα1-adrenergicreceptorsandactsasafunctionalinhibitorofacidsphingomyelinase(FIASMA).
References
LlorcaPM,SpadoneC,SolO,etal.Efficacyandsafetyofhydroxyzineinthetreatmentofgeneralizedanxietydisorder:a3-monthdouble-blindstudy.JClinPsychiatry.2002Nov;63(11):1020-7.PMID:12444816.
MinogiannisP,El-MansouryM,BetancesJA,etal.Hydroxyzineinhibitsneurogenicbladdermastcellactivation.IntJImmunopharmacol.1998Oct;20(10):553-63.PMID:9839659.
HaraguchiK,ItoK,KotakiH,etal.Predictionofdrug-inducedcatalepsybasedondopamineD1,D2,andmuscarinicacetylcholinereceptoroccupancies.DrugMetabDispos.1997Jun;25(6):675-84.PMID:9193868.
SnowmanAM,SnyderSH.Cetirizine:actionsonneurotransmitterreceptors.JAllergyClinImmunol.1990Dec;86(6Pt2):1025-8.PMID:1979798.