Description
IcilinisanagoNISTattransientreceptorpotentialmelastatin8(TRPM8)channels;itmayblocktransientreceptorpotentialvanilloid3(TRPV3)channels.Icilindisplaysbothhyperalgesicandanalgesicactivitiesaswellasanti-inflammatoryandanticancerproperties.ActivationofTRPM8channelsinduceshyperalgesiaandallodynia,butlong-termactivationdesensitizesthechannelstoinducepainrelief.Likementhol,icilinactsasacoolingagent,asTRPM8channelsarecold-sensitive.Inanimalmodelsofcolitis,icilindecreaseslevelsofpro-inflammatorycytokines.IcilininhibitscellmotilityinpancreaticductaladenocarcinomacellsandalsodecreaseslevelsofE2F1andinducesG1phasecellcyclearrestinprostatecancercells.
References
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CucuD,ChiritoiuG,PetrescuS,etal.Characterizationoffunctionaltransientreceptorpotentialmelastatin8channelsinhumanpancreaticductaladenocarcinomacells.Pancreas.2014Jul;43(5):795-800.PMID:24658318.
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LeeS,ChunJN,KimSH,etal.IcilininhibitsE2F1-mediatedcellcycleregulatoryprogramsinprostatecancer.BiochemBiophysResCommun.2013Nov29;441(4):1005-10.PMID:24239550.
RamachandranR,HyunE,ZhaoL,etal.TRPM8activationattenuatesinflammatoryresponsesinmousemodelsofcolitis.ProcNatlAcadSciUSA.2013Apr30;110(18):7476-81.PMID:23596210.
SherkheliMA,GisselmannG,HattH.Supercoolingagenticilinblocksawarmth-sensingionchannelTRPV3.ScientificWorldJournal.2012;2012:982725.PMID:22548000.
