Description
J-147isaphenylhydrazidethatexhibitsneuroprotectiveandcognitionenhancingactivities.Invitro,thiscompounddecreasesneuronalloss,oxidativestress,andglutamate-inducedneurotoxicity.J-147alsoamelioratesmemoryimpairmentinanimalmodelsofAlzheimer’sdisease.
References
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PriorM,DarguschR,EhrenJL,etal.TheneurotrophiccompoundJ147reversescognitiveimpairmentinagedAlzheimer"sdiseasemice.AlzheimersResTher.2013May14;5(3):25.PMID:23673233.
ChirutaC,ZhaoY,TangF,etal.Metabolismofapotentneuroprotectivehydrazide.BioorgMedChem.2013May15;21(10):2733-41.PMID:23582448.