Description
Mifepristoneisasyntheticsteroidthatexhibitsabortifacient,contraceptive,neuroprotective,cognitionenhancing,andantidepressantactivities.Mifepristoneinhibitstheglucocorticoidreceptorandprogesteronereceptor;itpreventsovulationandinducesendometrialdecidualdegeneration.Invitro,mifepristoneprotectshippocampalculturesagainstoxidativestressandcelldeathinducedbyamyloid-β(Aβ),glutamate,andH2O2,suggestingpotentialbenefitinthetreatmentofAlzheimer’sdisease.Mifepristonealsoimprovescognitivefunction,workingmemory,andspatialmemoryandimprovesymptomsofdepressioninclinicalsettings.