LKT/LAMOTRIGINE/L0349/100 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/LAMOTRIGINE/L0349/100 mg

LKT/LAMOTRIGINE/L0349/100 mg

商品编号： L0349-100mg

品牌： lktlabs

市场价： ¥5980.00

美元价： 3588.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDL0349

CasNo.84057-84-1

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Lamotrigineexhibitsantiepileptic/anticonvulsant,antidepressant,antinociceptive,andanxiolyticactivities.LamotrigineinhibitsR-typeCav2.3voltage-gatedCa2+channelsandvoltage-gatedNa+channels,suppressingreleaseofglutamate.Inanimalsundergoingtheforcedswimtest,lamotriginedecreasesimmobilitytime.Lamotriginealsoincreasespainthresholdsintheformalintestanddisplaysanxiolyticpropertiesintheconditionedemotionalresponsetest.Lamotriginemayalsoexhibitanti-inflammatoryactivity,asitdecreaseslevelsofIL-1β,IL-2,andTNF-αinvitro.

ProductInfo

CasNo.	84057-84-1
Purity	≥98%
Formula	C₉H₇Cl₂N₅
FormulaWt.	255.01
ChemicalName	6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
IUPACName	6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
MeltingPoint	216-218°C
Solubility	WarmDMSOto20mg/mL,warmethanolto25mM,methanol
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	L0349InfoSheetPDF

References

HimmerichH,BartschS,HamerH,etal.ImpactofmoodstABIlizersandantiepilepticdrugsoncytokineproductionin-vitro.JPsychiatrRes.2013Nov;47(11):1751-9.PMID:23978396.

DibuéM,KampMA,AlpdoganS,etal.Cav2.3(R-type)calciumchannelsarecriticalformediatinganticonvulsiveandneuroprotectivepropertiesoflamotrigineinvivo.Epilepsia.2013Sep;54(9):1542-50.PMID:23772876.

MunroG,ErichsenHK,MirzaNR.Pharmacologicalcomparisonofanticonvulsantdrugsinanimalmodelsofpersistentpainandanxiety.Neuropharmacology.2007Oct;53(5):609-18.PMID:17714743.

KasterMP,RauppI,BinfaréRW,etal.Antidepressant-likeeffectoflamotrigineinthemouseforcedswimmingtest:evidencefortheinvolvementofthenoradrenergicsystem.EurJPharmacol.2007Jun22;565(1-3):119-24.PMID:17433291.

LeachMJ,MardenCM,MillerAA.Pharmacologicalstudiesonlamotrigine,anovelpotentialantiepilepticdrug:II.NeuRochemicalstudiesonthemechanismofaction.Epilepsia.1986Sep-Oct;27(5):490-7.PMID:3757936.

OokuboM,KanaiH,AokiH,YamadaN.AntidepressantsandmoodstabilizerseffectsonhistonedeacetylaseexpressioninC57BL/6mice:brainregionspecificchanges.JPsychiatrRes.2013Sep;47(9):1204-1214.PMID:23777937.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂