Lomerizineisaninhibitorofvoltage-gatedL-typeandT-typeCa2+channelsaswellastransientreceptorpotential(TRP5)channels.Lomerizineisclinicallyusedtotreatmigraineandvertigo.Lomerizineexhibitsneuroprotectivebenefitinanimalmodelsofamyotrophiclateralsclerosis(ALS),decreasingglutamateexcitotoxicity,Ca2+overload,andmitochondrialdysfunction.Inotheranimalmodels,lomerizineprotectsagainstNMDA-inducedretinaldamageandneurodegeneration.
| CasNo. | 101477-54-7 |
|---|---|
| Purity | ≥98% |
| Formula | C27H30F2N2O3•2HCl |
| FormulaWt. | 541.47 |
| ChemicalName | 1-[Bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazinedihydrochloride |
| IUPACName | 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine;dihydrochloride |
| Synonym | Lomerizinedihydrochloride |
| MeltingPoint | 204-207°C |
| Appearance | Whiteoroff-WhiteCrystallinePowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | L5751MSDSPDF |
|---|---|
| InfoSheet | L5751InfoSheetPDF |
TranLT,GentilBJ,SullivanKE,etal.Thevoltage-gatedcalciumchannelblockerlomerizineisneuroprotectiveinmotorneuronsexpressingmutantSOD1,butnotTDP-43.JNeuRochem.2014Apr9.[Epubaheadofprint].PMID:24716897.
InoueY,YabeT.Lomerizinetherapyforthetreatmentofbenignparoxysmalvertigoofchildhoodtransitioningintoatypicalbasilarmigraine:Acasereport.ExpTherMed.2013Jun;5(6):1573-1575.PMID:23837033.
ItoY,NakamuraS,TanakaH,etal.Lomerizine,aCa2+channelblocker,protectsagainstneuronaldegenerationwithinthevisualcenterofthebrainafterretinaldamageinmice.CNSNeurosciTher.2010Apr;16(2):103-14.PMID:19788586.
FitzgeraldM,BartlettCA,HarveyAR,DunlopSA.Earlyeventsofsecondarydegenerationafterpartialopticnervetransection:animmunohistochemicalstudy.JNeurotrauma.2010Feb;27(2):439-452.PMID:19852581.
