Description
LoxoprofenisanonselectiveinhibitorofCOX-1andCOX-2thatexhibitspropertiestypicalofmostnon-steroidalanti-inflammatorydrugs(NSAIDs),includinganti-inflammatory,analgesic,andantinociceptiveactivities.Invivo,loxoprofendecreasesnoxiousheat-evokedneuralresponses.Inothermodels,loxoprofendecreaseslevelsofthromboxaneB2(TxB2)andprostaglandinsE2(PGE2)andF1(PGF1),decreasingaorticatheroscleroticlesions.Additionally,loxoprofendecreasesnocturiainsubjectswithbenignprostatichyperplasia(BPH)byincreasingbladdercapacity.
References
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