Description
Lumiracoxibisanon-steroidalanti-inflammatorydrug(NSAID)thatactsasaninhibitorofCOXenzymeswithspecificityforCOX-2.LikeotherNSAIDs,lumiracoxibexhibitsanti-inflammatory,analgesic,antipyretic,andantinociceptiveactivities.Inanimalmodelsofmetabolicsyndrome,lumiracoxibreversesvascularremodelingandinflammation.Inanimalmodelswithexperimentalautoimmuneencephalitis(EAE,atranslationalmodelofmultiplesclerosis),lumiracoxibinhibitslymphocyteresponsesanddecreasesdiseaseseverity;insimilarinvitromodels,lumiracoxibinhibitsTcellproliferationandmodulatesexpressionofT-bet,IL-10,andIFN-γ.Thiscompoundmayalsoinhibitthromboxanereceptors.Additionally,lumiracoxibexhibitssomeanticancerpotential,inducingG0/G1cellcyclearrestandapoptosisandinhibitingproliferationinnon-smallcelllungcancer(NSCLC)celllines.
References
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