MDL29951actsasanagoNISTatGPR17,inhibitingmaturationofprimaryoligodendrocytesandpotentiallypromotingmyelinrepairinmodelsofmultiplesclerosis.MDL29951alsoinhibitsNMDAreceptorsattheglycinesiteaswellasfructose1,6-bisphosphatase.Thiscompounddisplaysneuromodulatory,anticonvulsant,andantinociceptiveactivities.Invivo,MDL29951inhibitsformalin-inducedlicking.Inanimalmodelsofseizures,thiscompoundincreasesthresholdsforthedevelopmentofchemically-inducedseizures.
| CasNo. | 130798-51-5 |
|---|---|
| Purity | ≥98% |
| Formula | C12H9Cl2NO4 |
| FormulaWt. | 302.11 |
| IUPACName | 3-(2-Carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylicacid |
| Synonym | MDL29951 |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | M1444InfoSheetPDF |
|---|
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