Description
Mefenamicacidisafenamatenon-steroidalanti-inflammatorydrug(NSAID)thatexhibitsanti-inflammatory,analgesic,neuroprotective,anticancer,andneuromodulatoryactivities.Mefenamicacidisanon-selectiveinhibitorofCOX-1andCOX-2thatalsopotentiatesactivityatGABA-Areceptors.Inanimalmodelsofcerebralischemia,mefenamicaciddecreasesinfarctvolume,edema,andischemicbraindamage.Additionally,thiscompoundinhibitsproliferationincoloncancercellsbyalteringcellcycleregulatorsandinhibitingstore-operatedCa2+entryintocells.
References
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WeissH,AmbergerA,WidschwendterM,etal.Inhibitionofstore-operatedcalciumentrycontributestotheanti-proliferativeeffectofnon-steroidalanti-inflammatorydrugsinhumancoloncancercells.IntJCancer.2001Jun15;92(6):877-82.PMID:11351310.
HalliwellRF,ThomasP,PattenD,etal.Subunit-selectivemodulationofGABAAreceptorsbythenon-steroidalanti-inflammatoryagent,mefenamicacid.EurJNeurosci.1999Aug;11(8):2897-905.PMID:10457186.
